Gamma amino butyric acid (GABA) is a neurotransmitter that actually reduces excess neurotransmission in the brain. When used supplementally, it generally has a mild tranquilizing effect, as only a small portion of what you take actually gets in to the brain. It works by limiting excess activity in areas of the brain associated with anxiety. When GABA binds to the surface of certain neuronal receptor sites, the neurons become less actice, which may tend to decrease anxiety. When taken with GABA, B-vitamins such as inositol, niacinamide, and bitamin B6 enhance itys ability to bind to receptor sites. Typically, GABA is taken in 200 to 750 milligram doses once or twice daily. Don't exceed 1500 milligrams in a twenty-four hour peroid except in consultation with your doctor. It's a good idea to take GABA on an empty stomach or with a carbohydrate snack like toast of crackers, which tends to enhance the sedative effect. Avoid taking GABA with protein, as this will tend to compete with the absorption of GABA.
GABA, in combination with the amino acids taurine and glycine, has been used to help people wean themselves off of benzodiazepine tranquilzers such as Xanax, Atrivan, and Klonopin.
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